Why the study?
The effectiveness of calcium channel blockers before and after contrast exposure for CI-AKI prophylaxis compared to ACE inhibitors had not been explored by many studies.
Does calcium channel blocker monotherapy reduce contrast-induced acute kidney injury compared to ACE inhibitor monotherapy in patients undergoing coronary angiography?
Does calcium channel blocker monotherapy reduce contrast-induced acute kidney injury compared to ACE inhibitor monotherapy in patients undergoing coronary angiography?
There is no significant difference in the incidence of contrast-induced acute kidney injury between patients receiving calcium channel blockers versus ACE inhibitors prior to coronary angiography.
No differential CI-AKI risk observed with CCB versus ACEI; leaves open effects on contrast nephropathy and requires randomized confirmation.
Aim: To evaluate the effectiveness of contrast-induced acute kidney injury (CI-AKI) prophylaxis retrospectively, using calcium channel blockers (CCB) before and after contrast exposure and comparing them with patients using angiotensin converting enzyme inhibitors (ACEI), which has not been explored by many studies. Methods: The study was performed in Afyon Kocatepe University, Faculty of Medicine Research Hospital, Cardiology Department between January 2014 and June 2016. Eighty patients using dihydropyridine (amlodipine 10 mg), non-dihydropyridine (diltiazem 60 mg) CCB or ACEI in the form of monotherapy before coronary angiography were included. Results: In the CCB and ACEI group, CI-AKI development rates were 15.7% (n=8) and 24.1% (n=7), respectively (p = 0.383; Fisher's exact test). When the CCB group was evaluated as dihydropyridine and non-dihydropyridine subsets, CI-AKI development rates were found to be similar as well (p = 0.445; Fisher's exact test) in each subset.
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Tel et al. (2020) studied this question.
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