Single positive culture was encountered in 61/235 patients (26%) with Staphylococcus aureus in blood culture over a 2-y period. It represented either true bacteremia (n = 52 cases; 85.2%) or contamination (n = 9; 14.8%). In comparison to cases with < or = 2 positive cultures, these patients did not have less severe disease or a lower incidence of complications.
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Khatib et al. (2002) studied this question.
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