Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis

Figures

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  Figure 1.. PRISMA flow diagram of the study selection process. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

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  Figure 2.. Pooled sensitivity and specificity of angiopoietin-2 for diagnosis of acute pancreatitis with organ failure from the included studies: Whitcomb et al.17 (two studies), Espinosa et al.,34 Buddingh et al.,31 Zhang et al.,32 Dumnicka et al.,35 and Huang et al.33

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  Figure 3.. Summary receiver operating characteristic (sROC) curve of Ang-2 for diagnosis of AP with OF.. Ang-2, angiopoietin; OF, organ failure; AP, acute pancreatitis; SENS, sensitivity; SPEC, specificity, AUC, area under the curve. Circled numbers indicate studies: 1 = Espinosa et al.,34 2 = Whitcomb et al.,17 3 = Buddingh et al.,31 4 = Dumnicka et al.,35 5 = Whitcomb et al.,17 6 = Zhang et al.,32 and 7 = Huang et al.33

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  Figure 4.. Subgroup analysis of potential heterogeneity within the included studies. Meta-regression analysis for Ang-2 with following variables: sample size ≥100 or not; prospective or not; Ang-2 assay with Asia or not; definition of OF (Atlanta classification or not); Ang-2 sampling time of admission ≥24 hours or not; admission time of AP onset? 24 hours or not; where yes =1, not = 0. Ang-2, angiopoietin-2; OF, organ failure; AP, acute pancreatitis.

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  Figure 5.. Sensitivity analysis of the included studies: Whitcomb et al.17 (two studies), Espinosa et al.,34 Buddingh et al.,31 Zhang et al.,32 Dumnicka et al.,35 and Huang et al.33

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  Figure 6.. Fagan’s nomogram of the Ang-2 test for diagnosis of AP with OF. LR, likelihood ratio; Prob, probability; Pos, positive; Neg, negative; Ang-2, angiopoietin; OF, organ failure; AP, acute pancreatitis.

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  Figure 7.. Deeks’ funnel plot for the assessment of potential publication bias of the included studies ESS, effective sample size. Circled numbers indicate studies: 1 = Espinosa et al.,34 2 = Whitcomb et al.,17 3 = Buddingh et al.,31 4 = Dumnicka et al.,35 5 = Whitcomb et al.,17 6 = Zhang et al.,32 and 7 = Huang et al.33