Key result
In patients with acute liver failure, median Angiopoietin-2 levels were higher in those reaching death or transplantation (16.8 ng/mL) versus those with transplant-free recovery (10.0 ng/mL).
Why the study?
Do elevated Angiopoietin-2 levels predict death or emergency liver transplantation in patients with acute liver failure?
Observational (n=57)
No
Do elevated Angiopoietin-2 levels predict death or emergency liver transplantation in patients with acute liver failure?
Circulating Angiopoietin-2 correlates with multiple organ dysfunction syndrome and independently predicts death or emergency liver transplantation in patients with acute liver failure.
May aid risk stratification in acute liver failure; hypothesis-generating and requires prospective validation before guiding decisions.
No takes yet. Share an insight, caveat, or question.
Hadem et al. (2012) conducted an observational in Acute liver failure (n=57). Angiopoietin-2 levels vs. Healthy controls and patients with transplant-free recovery was evaluated on Composite end point of death or emergency liver transplantation. In patients with acute liver failure, median Angiopoietin-2 levels were higher in those reaching death or transplantation (16.8 ng/mL) versus those with transplant-free recovery (10.0 ng/mL).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: