Key result
Elevated plasma angiopoietin-2 levels in septic shock were associated with percent fluid overload at baseline, acute kidney injury, and 28-day mortality.
Cohort (n=341)
Yes
In human septic shock, elevated plasma angiopoietin-2 levels are significantly associated with increased fluid overload, organ dysfunction, and mortality, suggesting a role in vascular leakage.
Answers are grounded in this paper and cite their sources.
Angiopoietin-2 may aid risk stratification in septic shock; leaves open whether it is a viable therapeutic target.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Fisher et al. (2016) conducted a cohort in septic shock (n=341). Elevated plasma angiopoietin-2 levels was evaluated on percent fluid overload at baseline (rs = 0.18, p=0.0008). Elevated plasma angiopoietin-2 levels in septic shock were associated with percent fluid overload at baseline (rs=0.18; p=0.0008), acute kidney injury (AUC 0.73), and 28-day mortality (p=0.027).
Synapse has enriched 10 related papers. Consider them for comparative context: