Why the study?
The study investigated plasma levels of angiopoietin-1 and angiopoietin-2 and their association with clinical outcomes of sepsis.
Do plasma angiopoietin-2 levels predict the development of septic shock in patients with severe sepsis?
Observational (n=200)
No
Do plasma angiopoietin-2 levels predict the development of septic shock in patients with severe sepsis?
Plasma angiopoietin-2 levels show high discriminative ability for predicting septic shock in patients with severe sepsis.
Answers are grounded in this paper and cite their sources.
Angiopoietin-2 may aid sepsis prognostication; hypothesis-generating and should not yet change practice.
Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778). Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.
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Duyen et al. (2022) conducted an observational in Severe sepsis and septic shock (n=200). Plasma angiopoietin-2 levels vs. Severe sepsis without shock was evaluated on Discrimination of septic shock from severe sepsis (AUC 0.778, p=<0.0001).
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