Key result
Serum Ang-2 mRNA levels at ICU admission significantly predicted 28-day mortality in septic shock patients with an AUC of 0.82, demonstrating higher accuracy than SOFA and APACHE II scores.
Why the study?
Angiopoietin 2 plays an integral role in sepsis pathophysiology, but its specific role and predictive value in septic shock have not been defined.
Does serum Ang-2 mRNA level predict 28-day mortality in patients with septic shock?
Cohort (n=95)
No
Does serum Ang-2 mRNA level predict 28-day mortality in patients with septic shock?
Effect estimate: AUC 0.82
Absolute Event Rate: 0.82% vs 0.76%
p-value: p=<0.01
Serum Ang-2 mRNA levels are significantly elevated in septic shock and may serve as a better predictive biomarker for 28-day mortality than SOFA and APACHE II scores.
Ang-2 mRNA may support risk stratification in septic shock; hypothesis-generating and requires prospective validation before clinical use.
It has been reported that angiopoietin 2 (Ang-2) plays an integral role in the pathophysiology of sepsis and many other inflammatory diseases. However, the specific role of Ang-2 in septic shock has not been defined. The aim of the present study was to assess the predictive value of serum Ang-2 in patients with septic shock. Clinical data of 85 patients with septic shock and 10 healthy controls admitted to the intensive care unit with a diagnosis of septic shock were collected between January 2020 and October 2020 at Tongji Hospital (Wuhan, China). The serum levels of Ang-2 mRNA were quantified using a quantitative real-time PCR assay. Ang-2, SOFA and APACHE II scores were retrospectively analyzed in relation to 28-day mortality. The area under the receiver operating characteristic (ROC) curve (AUC) was used to discriminate the accuracy of the prediction. Mean Ang-2 mRNA levels in the patients with septic shock were significantly higher than those in the healthy controls (P<0.05), and the Ang-2 levels showed a downwards trend over time following treatment. The three indicators (AUCs, SEMs, P-values) were Ang-2 (0.82, 0.03, P<0.01), SOFA score (0.76, 0.04, P<0.01), and APACHE II score (0.73, 0.04, P<0.01). The present study confirmed that Ang-2 mRNA levels were significantly elevated in septic shock. The Ang-2 mRNA level at ICU admission in a patient with septic shock could be a predictive biomarker for mortality.
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Feng et al. (2022) conducted a cohort in Septic shock (n=95). Serum Angiopoietin 2 (Ang-2) mRNA levels vs. SOFA and APACHE II scores was evaluated on 28-day mortality prediction (AUC) (AUC 0.82, p=<0.01). Serum Ang-2 mRNA levels at ICU admission significantly predicted 28-day mortality in septic shock patients with an AUC of 0.82, demonstrating higher accuracy than SOFA and APACHE II scores.
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