Key result
Elevated circulating angiopoietin-2 independently predicted 30-day mortality in critically ill medical patients (HR 1.033 per ng/ml increase).
Why the study?
Does circulating Ang-2 predict 30-day mortality in critically ill medical patients?
Cohort (n=72)
No
Does circulating Ang-2 predict 30-day mortality in critically ill medical patients?
Hazard Ratio: 1.033 (95% CI 1.012–1.055)
p-value: p=0.002
Elevated circulating Ang-2 at ICU admission is a strong, independent predictor of 30-day mortality in critically ill medical patients.
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May refine ICU risk stratification; hypothesis-generating for Ang-2-targeted therapies in critical illness.
Kümpers et al. (2008) conducted a cohort in Critical illness (medical ICU patients) (n=72). Circulating Angiopoietin-2 (Ang-2) vs. Lower Ang-2 levels was evaluated on 30-day survival (HR 1.033, 95% CI 1.012-1.055, p=0.002). Elevated circulating angiopoietin-2 independently predicted 30-day mortality in critically ill medical patients (HR 1.033 per ng/ml increase).