A Visualized Guideline for Cancer Chemotherapy Induced Neuropathic Pain in Mice Using Cisplatin

Neuropathic pain associated with cancer chemotherapy remains an important source of trouble for different cancer therapy regimens. Cisplatin is a platinum based agent widely prescribed in clinics and induces dose?dependent painful sensory neuropathy; modeling of its toxicity in animal models is, therefore, of interest. Among various species of rodent models, mice are used frequently to reproduce the neuropathic condition. Special considerations are required for using mice in this procedure. Different steps, considerations and approaches including cisplatin intravenous injection as well as behavioral assessment of cisplatin sensory neuropathy are explained in this paper.