Mulford et al. (5) recently investigated the correlation between cerebrospinal fluid (CSF) leukocyte count and enteroviral reverse transcription (RT)-PCR results in cases of suspected meningitis. They found that CSF pleocytosis was absent in 30% of infants aged ≤2 months with a positive enteroviral RT-PCR result, compared with 2% of patients aged 2 months to 18 years and 0% of patients aged >18 years. In their study, pleocytosis was defined as a CSF white cell count of >22 cells/mm3 for neonates, >15 cells/mm3 for infants aged 1 to 2 months, and >5 cells/mm3 for patients aged >2 months.
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Graham et al. (2005) studied this question.
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