Key result
Insulin-resistance syndrome risk factors rather than hyperglycemia per se seem to affect the risk of cardiovascular disease in patients with both type 1 and type 2 diabetes.
Insulin-resistance syndrome risk factors, rather than hyperglycemia alone, appear to be the primary drivers of cardiovascular disease risk in patients with diabetes.
ardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with diabetes; in type 1 diabetes, CVD typically is related to diabetic nephropathy. 1 In both type 1 (DCCT, the Diabetes Control and Complications Trial) and type 2 diabetes (UKPDS, the United Kingdom Prospective Diabetes Study), intensive glucose control affects macrovascular disease less than microvascular disease.2,3 The pathophysiology of CVD in patients with diabetes is complex.Insulin-resistance syndrome risk factors rather than hyperglycemia per se seem to affect the risk of CVD in patients with both type 1 4 and type 2 diabetes.
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Festa et al. (2005) conducted a review in Cardiovascular disease in diabetes. Insulin-resistance syndrome risk factors rather than hyperglycemia per se seem to affect the risk of cardiovascular disease in patients with both type 1 and type 2 diabetes.
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