Why the study?
Does acetylsalicylic acid reduce circulating platelet aggregates and myocardial ischaemia in open chest dogs with acute myocardial ischaemia?
Population
Open chest dogs
Design
Preclinical
Authors
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Canine findings should not inform clinical aspirin use in ischaemia; leaves open effects on platelet aggregates in human acute coronary syndromes.
Does acetylsalicylic acid reduce circulating platelet aggregates and myocardial ischaemia in open chest dogs with acute myocardial ischaemia?
In a canine model, acute myocardial ischemia increases coronary sinus platelet aggregates, which are not significantly reduced by aspirin during the ischemic event despite a reduction in ischemia severity.
Harald Vik‐Mo (1977) studied this question.
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