Why the study?
Do nicotinic acid or sodium salicylate alter coronary blood flow or reduce myocardial ischemic injury in dogs with acute coronary occlusion?
Do nicotinic acid or sodium salicylate alter coronary blood flow or reduce myocardial ischemic injury in dogs with acute coronary occlusion?
Antilipolytic agents nicotinic acid and sodium salicylate reduce acute myocardial ischemic injury in dogs, likely by lowering oxygen demand rather than altering coronary blood flow.
Answers are grounded in this paper and cite their sources.
Should not change acute coronary occlusion management; leaves open metabolic modulation of ischemic injury for further study.
The effects of the antilipolytic agents nicotinic acid (NA) and sodium salicylate (SS) on the distribution of coronary blood flow during acute myocardial ischaemia were studied in open chest dogs. Fifteen min following experimental coronary artery occlusion, blood flow in the ischaemic myocardium was on average 28% of flow in the non-ischaemic myocardium. The reduction in blood flow in the ischaemic mycardium was more pronounced in the endocardial than in epicardial halves of the myocardium. No significant change in blood flow was observed after administration of NA or SS in either the ischemic or nonischemic part of the myocardium. Both drugs reduced the extent of myocardial ischaemic injury as shown by reduced epicardial ST-segment elevations. Arterial concentrations of fatty acids were lowered by NA or SS, whereas the mechanical activity of the heart remained unchanged. It is concluded that the reduction of acute myocardial ischaemic injury effected by NA or SS is not due to changes in myocardial blood flow, but more likely to lower myocardial oxygen demand related to reduced fatty acid utilization.
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Harald Vik‐Mo (1977) studied this question.
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