Why the study?
Does pretreatment with antilipolytic agents (nicotinic acid or sodium salicylate) alter lipolysis and free fatty acid metabolism during induced myocardial ischaemia in open-chest dogs?
Population
open-chest dogs with induced myocardial ischaemia by coronary artery occlusion
Comparison
pretreatment with nicotinic acid or sodium… vs basal state
Design
Preclinical
Authors
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May attenuate experimental ischemic injury via reduced lipolysis; leaves open translation to human ACS trials.
Does pretreatment with antilipolytic agents (nicotinic acid or sodium salicylate) alter lipolysis and free fatty acid metabolism during induced myocardial ischaemia in open-chest dogs?
Antilipolytic agents such as nicotinic acid or sodium salicylate may reduce the severity of acute ischaemic injury by inhibiting myocardial lipolysis and reducing free fatty acid extraction.
Vik‐Mo et al. (1979) studied this question.
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