Key result
Inhibiting hormone-sensitive lipase activity reduced the extent and severity of myocardial ischemic injury and heart failure following acute coronary artery occlusion in dogs.
Why the study?
Does antilipolytic treatment reduce myocardial ischaemic injury and heart failure in a dog model of acute coronary occlusion?
Population
Dog model of acute coronary artery occlusion
Comparison
Antilipolytic treatment vs Control occlusion without treatment
Design
Preclinical
Authors
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Supports antilipolytic strategies in acute ischemia; hypothesis-generating for human translation.
Does antilipolytic treatment reduce myocardial ischaemic injury and heart failure in a dog model of acute coronary occlusion?
Inhibition of lipolysis may reduce myocardial ischemic injury and subsequent heart failure following acute coronary occlusion in a canine model.
John Kjekshus (1974) studied this question. Inhibiting hormone-sensitive lipase activity reduced the extent and severity of myocardial ischemic injury and heart failure following acute coronary artery occlusion in dogs.
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