Why the study?
What are the clinical features of enteric adenovirus infection compared to other adenovirus and rotavirus infections in infants with gastroenteritis?
What are the clinical features of enteric adenovirus infection compared to other adenovirus and rotavirus infections in infants with gastroenteritis?
Enteric adenovirus infections in infants, particularly Ad40, are characterized by watery diarrhea and vomiting, though these symptoms occur less frequently than in rotavirus infections.
Ad40 may cause more symptomatic gastroenteritis than Ad41 in infants; extends observational comparisons but leaves open prospective validation.
During the period December 1984 to October 1988, adenoviruses (Ads) were isolated on 119 occasions (1.6%) from stool samples of patients with gastroenteritis. By DNA restriction analysis, 85 enteric adenoviruses (EAds) were identified. Sixty-seven patients with these infections were studied, of whom 18 had Ad40, 30 had Ad41 and 19 had untyped Ad infections. The incidence of Ad infection was high in children between 6 and 11 months of age. The illness was characterized by watery diarrhea (whitish in one third of patients), continuing for a mean of 4.5 days, and vomiting, which occurred more often in patients with EAds than in other types of infection. Diarrhea, fever and vomiting were seen significantly more frequently in patients with Ad40 than in Ad41 infection. Diarrhea and vomiting were also seen significantly more frequently in patients with EAds than in Ads infection. Diarrhea, fever and vomiting were observed more frequently in patients with rotavirus than EAds infection.
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Shinozaki et al. (1991) studied this question.
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