Key result
Enteric adenovirus infection was detected in 10.9% of hospitalized children under 5 years with non-rotavirus diarrhea in northeast India, and was significantly associated with severe diarrhea and restlessness.
Cross-Sectional (n=238)
No
Enteric adenovirus is a significant viral etiological agent for acute gastroenteritis among children in Northeast India, particularly during warmer months, and is associated with severe diarrhea and restlessness.
Supports adenovirus testing consideration in severe non-rotavirus diarrhea in northeast Indian children; hypothesis-generating and requires prospective validation before practice change.
Globally enteric adenovirus has become the second leading cause of viral diarrhea. Present investigation was undertaken to understand the adenoviral etiology of diarrhea among hospitalized children in Assam, northeast India. Materials and methods: Over a period of two years (2013-2015), 455 faecal samples were collected from hospitalized children aged <5 years with diarrhea from Assam, northeast India for screening of rotavirus antigen. A total of 238 samples were rotavirus antigen negative and are screened for adenovirus antigen by ELISA and followed by PCR. Results: Present investigation revealed enteric adenovirus infection in hospitalized children <5 years to be 10.9% (26/238). Prevalence was higher among infants (16.6%) and females (15.1%). Moreover, severe diarrhea (10 times) 14.9% (P=0.047) and restlessness 50% (P=0.002) is significantly higher in enteric adenovirus infected children. Enteric adenovirus infection was observed sporadically throughout the year; however infection was higher during warmer months (17%) than cooler months (7.3%) (P=0.0001). Adenovirus sequence analysis of the hexon gene showed adenovirus F type-41 to be the predominant serotype circulating in the study region. Analysis of the adenovirus fiber protein of the present study confirmed 15 amino acid deletions from the 15 th repeat motif of the shaft region. Conclusions: Present data demonstrated that enteric adenovirus could be considered an important viral etiological agent for acute gastroenteritis among children in northeast India along with other etiology.
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Borkakoty et al. (2016) conducted a cross-sectional in Non-rotavirus acute watery diarrhea (n=238). Enteric adenovirus infection vs. Non-adenovirus infected children was evaluated on Prevalence of enteric adenovirus infection (95% CI 6.9-14.8). Enteric adenovirus infection was detected in 10.9% of hospitalized children under 5 years with non-rotavirus diarrhea in northeast India, and was significantly associated with severe diarrhea and restlessness.
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