Key result
Rotavirus is linked to acute gastroenteritis, detected in ~16% of pediatric cases versus healthy controls.
Why the study?
The role of enteric-type adenoviruses and rotaviruses in mild and severe acute gastroenteritis among children younger than 5 years was unclear.
Comparison
Children with acute gastroenteritis vs age-matched nondiarrheal controls
Design
Case-control study at an urban hospital and a rural health center
Authors
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Supports rotavirus as a leading cause of pediatric gastroenteritis in India; extends prior evidence to urban and rural centers but remains hypothesis-generating.
Case-Control (n=1,304)
Yes
Absolute Event Rate: 15.2% vs 1.9%
p-value: p=<0.001
Rotavirus is a significant cause of severe acute gastroenteritis in Indian children, and adenoviruses other than types 40 and 41 may also play a diarrheagenic role.
Bhan et al. (1988) conducted a case-control in Acute gastroenteritis (n=1,304). Rotavirus and adenovirus infection vs. Nondiarrheal controls was evaluated on Rotavirus detection at the urban hospital (p=<0.001). Rotavirus was detected significantly more often in children with acute gastroenteritis than in controls at both urban (15.2% vs 1.9%) and rural (16.5% vs 2.9%) centers (P<0.001).
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