September 1, 1999Journal of Pediatric Gastroenterology and Nutrition

Effect of Rhesus Rotavirus Vaccine on Enteric Adenovirus-Associated Diarrhea in Children

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Why the study?

Does the RRV-TV rotavirus vaccine reduce the incidence or severity of enteric adenovirus-associated diarrhea in children?

Structured PICO

Does the RRV-TV rotavirus vaccine reduce the incidence or severity of enteric adenovirus-associated diarrhea in children?

Population

2,273 Finnish infants (aged 50-110 days at recruitment) who received all three doses of the study vaccine or placebo.

Intervention

Rhesus-human reassortant tetravalent (RRV-TV) rotavirus vaccine, three doses administered between 2 and 7 months of age.

Comparator

Placebo (three doses).

Outcome

Incidence and clinical severity (including duration of diarrhea, vomiting, and fever) of enteric adenovirus-associated gastroenteritis (Ad 40 and Ad 41).

The RRV-TV rotavirus vaccine significantly shortened the duration of watery diarrhea in children with enteric adenovirus-associated gastroenteritis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support RRV-TV for adenovirus gastroenteritis; extends rotavirus vaccine benefits to heterologous pathogens.

Cite This Study

Koskenniemi et al. (1999) studied this question.

synapsesocial.com/papers/6a8a50ce788d49930fcbf982 https://doi.org/10.1097/00005176-199909000-00026

View Full Paper

Ask AI

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Effect of Rhesus Rotavirus Vaccine on Enteric Adenovirus-Associated Diarrhea in Children

Structured PICO

Discussion

Implication

Cite This Study

Effect of Rhesus Rotavirus Vaccine on Enteric Adenovirus-Associated Diarrhea in Children

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider