What question did this study set out to answer?

To characterize the clinical manifestations, transmission dynamics, and laboratory features of an ECHO virus type 9 epidemic alongside co-circulating enteroviruses in a residential community.

July 1, 1960PEDIATRICS

Clinical and Epidemiologic Observations on Enterovirus Infection in a Circumscribed Community During an Epidemic of Echo 9 Infection

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Why the study?

What are the clinical and epidemiologic characteristics of ECHO 9 and Coxsackie B virus infections during an epidemic in a circumscribed community?

Population

Residents of a circumscribed community (housing development) during an epidemic of ECHO virus, type 9.

Design

Cohort

Authors

MLMartha L. LepowAlbany Medical Center Hospital DCDavid H. CarverUniversity of Ottawa FRFrederick C. RobbinsNational Academy of Medicine

Discussion

Member takes

Implication

Age-specific manifestations may inform clinical suspicion in enteroviral outbreaks; leaves open generalizability of infection rates beyond this cohort.

Key Points

To characterize the clinical manifestations, transmission dynamics, and laboratory features of an ECHO virus type 9 epidemic alongside co-circulating enteroviruses in a residential community.
Conducted a clinical, epidemiologic, and virologic investigation within a defined housing development experiencing an epidemic of ECHO virus type 9.
Collected fecal specimens to assess viral shedding duration and performed serologic analyses across pediatric and adult cohorts to detect ECHO 9 and co-circulating Coxsackie B4 and B5 viruses.
Clinical presentation was age-dependent: young children primarily developed an exanthem and exhibited the highest incidence of illness, while older individuals predominantly presented with signs of central nervous system irritation, with no serious complications observed.
ECHO 9 virus was isolated from feces significantly more frequently in ill young children than in ill adults despite adult seroconversion, viral shedding rarely persisted beyond 14 days, and inapparent infection rates were low.
Concurrent Coxsackie B4 and B5 infections produced similar clinical manifestations to ECHO 9 but lacked an exanthem, demonstrated higher rates of inapparent infection, and rarely presented as dual simultaneous infections.

Structured PICO

What are the clinical and epidemiologic characteristics of ECHO 9 and Coxsackie B virus infections during an epidemic in a circumscribed community?

Population

Residents of a circumscribed community (housing development) during an epidemic of ECHO virus, type 9.

Outcome

Clinical manifestations, epidemiology, and laboratory findings of ECHO 9 and Coxsackie B virus infections.

ECHO 9 and Coxsackie B viruses can co-circulate during an epidemic, causing age-dependent clinical manifestations with differing rates of inapparent infection.

Cite This Study

Lepow et al. (1960) studied this question.

synapsesocial.com/papers/6a8a5189336687a3262e50b4 https://doi.org/10.1542/peds.26.1.12

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Implication

Age-specific manifestations may inform clinical suspicion in enteroviral outbreaks; leaves open generalizability of infection rates beyond this cohort.

Clinical and Epidemiologic Observations on Enterovirus Infection in a Circumscribed Community During an Epidemic of Echo 9 Infection

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Clinical and Epidemiologic Observations on Enterovirus Infection in a Circumscribed Community During an Epidemic of Echo 9 Infection

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider