Why the study?
Does SKF 64139 reduce blood pressure in glucocorticoid-hypertensive rats?
Population
Conscious normotensive and glucocorticoid-hypertensive rats maintained for 2 weeks on a salt-deficient diet
Comparison
SKF 64139 via oral gavage; saralasin infusion… vs Vehicle (5% glucose solution)
Design
Preclinical
Follow-up
4 hours to 20 minutes
Authors
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Supports sympathetic role in glucocorticoid hypertension maintenance; leaves open translation to human therapy.
Does SKF 64139 reduce blood pressure in glucocorticoid-hypertensive rats?
The sympathetic nervous system appears to be the main vasoconstrictor system involved in the maintenance of established glucocorticoid hypertension in rats.
Waeber et al. (1983) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: