Population
In vitro biochemical model studying myosin Va, melanophilin, and Rab27a
Comparison
Melanophilin binding vs Myosin Va without melanophilin
Design
Preclinical
Authors
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No practice change; leaves open whether melanophilin activates myosin motors to conserve ATP in human cells.
This study demonstrates that the binding of a cargo molecule (melanophilin) directly activates myosin motor activity, suggesting a mechanism to avoid wasted ATP consumption.
Li et al. (2005) studied this question.
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