What question did this study set out to answer?

To investigate the tissue distribution, structural variations, antithrombin-III binding properties, and anticoagulant activities of heparins and heparan sulphates across diverse vertebrate species.

July 15, 1986Biochemical JournalOpen Access

Biological implications of the structural, antithrombin affinity and anticoagulant activity relationships among vertebrate heparins and heparan sulphates

View Full Paper

Ask AI

Bookmark

Authors

PHPeter HovinghSprint (United States)MPMichael W. PiepkornNorthwestern University ALAlfred LinkerNorthwestern University

Discussion

Member takes

Implication

Comparative analysis reveals structural and anticoagulant diversity in vertebrate heparins, suggesting heparan sulphate does not primarily provide vascular antithrombotic protection.

Key Points

To investigate the tissue distribution, structural variations, antithrombin-III binding properties, and anticoagulant activities of heparins and heparan sulphates across diverse vertebrate species.
Isolated heparins and heparan sulphates from diverse tissues across multiple vertebrate classes, including aquatic species, rabbits, and other mammals.
Characterized structural properties, determined antithrombin-III binding affinity fractions, and quantified anticoagulant potencies relative to commercial heparin standards.
Heparin displayed a restricted distribution, being absent from lower aquatic vertebrates and rabbits, while displaying anticoagulant activities ranging from approximately 50% to 150% of commercial heparin.
Anticoagulant activity roughly correlated with antithrombin-III affinity, though high-affinity fractions from low-activity heparins overlapped in potency with low-affinity fractions from highly active heparins.
Heparan sulphates were ubiquitously distributed across tissues and contained up to 5% high-affinity subfractions that exhibited modest anticoagulant potencies of 2 to 30 units/mg.

Cite This Study

Hovingh et al. (1986) studied this question.

synapsesocial.com/papers/6a8a537c5edafe343d9312b1 https://doi.org/10.1042/bj2370573

View Full Paper

Ask AI

Bookmark

Implication

Comparative analysis reveals structural and anticoagulant diversity in vertebrate heparins, suggesting heparan sulphate does not primarily provide vascular antithrombotic protection.

Biological implications of the structural, antithrombin affinity and anticoagulant activity relationships among vertebrate heparins and heparan sulphates

Discussion

Member takes

Implication

Key Points

Cite This Study

Biological implications of the structural, antithrombin affinity and anticoagulant activity relationships among vertebrate heparins and heparan sulphates

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider