Why the study?
Doxorubicin causes severe cardiotoxicity, and although its host gene ITCH is involved, whether the tumor-suppressive circular RNA CircITCH plays a role in doxorubicin-induced cardiotoxicity was unknown.
Population
hiPSC-CMs, human autopsy specimens with doxorubicin-induced cardiomyopathy, and mice
Comparison
CircITCH overexpression vs controls in doxorubicin-induced cardiotoxicity models
Design
Preclinical in vitro and in vivo translational study
Authors
Loading...
May offer a novel target for doxorubicin cardiotoxicity; hypothesis-generating and requires human validation before clinical consideration.
CircITCH represents a potential novel therapeutic target for doxorubicin-induced cardiotoxicity by mitigating cardiomyocyte injury through the miR-330-5p/SIRT6/Survivin/SERCA2a axis.
Han et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: