Why the study?
Does clopidogrel plus aspirin increase the risk of subdural hematoma compared with aspirin alone in patients with recent lacunar stroke, acute coronary syndromes, or atrial fibrillation?
Population
23,136 patients with recent lacunar stroke, acute coronary syndromes or atrial fibrillation, mean age 66…
Comparison
Clopidogrel plus aspirin for more than 7 days vs Aspirin alone
Design
Meta-analysis, Randomized clinical trials, Double-blind
Follow-up
mean 2.1 years per patient
Authors
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Clinicians should weigh subdural hematoma risk with clopidogrel-aspirin; extends bleeding safety data across lacunar stroke, ACS, and AF populations.
Does clopidogrel plus aspirin increase the risk of subdural hematoma compared with aspirin alone in patients with recent lacunar stroke, acute coronary syndromes, or atrial fibrillation?
Dual antiplatelet therapy with clopidogrel and aspirin significantly increases the risk of subdural hematoma compared to aspirin alone, though the absolute rate remains low at 1.1 per 1000 patient-years.
Bakheet et al. (2014) studied this question.
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