Association of Myosin I Alpha with Endosomes and Lysosomes in Mammalian Cells
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Population
Mouse hepatoma cell line BWTG3 and cellular clones producing BBMI, BBMID446, BBMI-Tail, or mock cells
Comparison
Overproduction of MMIalpha or production of… vs Mock cells
Design
Preclinical
Authors
Discussion
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Implication
Implicates MMIalpha in mammalian endocytic trafficking; hypothesis-generating for membrane dynamics but leaves open any clinical relevance.
Structured PICO
P
Population
Mouse hepatoma cell line BWTG3 and cellular clones producing BBMI, BBMID446, BBMI-Tail, or mock cells
I
Intervention
Overproduction of MMIalpha or production of nonfunctional truncated MMIalpha / truncated brush border myosin I proteins
C
Comparator
Mock cells (cells transfected with the vector without insert)
O
Outcome
Distribution of endocytic compartments and delivery of fluid phase markers from endosomes to lysosomessurrogate
MMIalpha is associated with endosomes and lysosomes and is involved in membrane trafficking between these compartments in mammalian cells.
Cite This Study
Raposo et al. (1999) studied this question.
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