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Preclinical studies have suggested that stem cell–based therapies possess the potential to improve stroke outcomes. Recently, the results of two early-stage clinical trials of stem cell therapy for chronic stroke have been published: the United Kingdom–based ReNeuron phase I clinical trial, called “Pilot Investigation of Stem Cells in Stroke” (PISCES, NCT01151124),1 and the United States–based SanBio phase I/IIa clinical trial, called “A Study of Modified Stem Cells in Stable Ischemic Stroke” (NCT01287936).
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Cesar V. Borlongan (2016) studied this question.
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