Population
Xenopus oocytes expressing wild-type and mutant (V[404,406]I, C322S) Kv4.1 or Kv1.4 potassium channels
Comparison
Mutations in the distal section of the S6 region… vs Wild-type Kv4.1 and Kv1.4 channels
Design
Preclinical
Authors
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Suggests pore residues modulate Kv4 gating in vitro; leaves open relevance to native cardiac Ito and arrhythmias.
Components of the pore's internal vestibule control both closing and inactivation in Kv4 K+ channels, providing structural insights into A-type potassium channel gating.
Jerng et al. (1999) studied this question.
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