Population
Xenopus oocytes expressing cloned Kir2 channel subunits (Kir2.3 and Kir2.1)
Comparison
Co-expression with G-protein betagamma subunits vs Co-expression with other G-protein subunits or…
Design
Preclinical
Authors
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May inform future arrhythmia therapies targeting Kir channels; leaves open translation of Kir2.3-Gβγ regulation to human cardiac disease.
G-protein betagamma subunits directly bind to and inhibit Kir2.3 inward rectifier potassium channels, revealing a specific molecular mechanism for channel regulation.
Cohen et al. (1996) studied this question.
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