Why the study?
The microminipig is an attractive model for cardiac electropharmacological applications meeting 3Rs considerations, but its in situ cardiovascular responses to multi-ionic channel inhibition needed characterization compared with dogs.
Does bepridil induce different cardiovascular electrophysiological responses in microminipigs compared to dogs?
Does bepridil induce different cardiovascular electrophysiological responses in microminipigs compared to dogs?
Microminipigs exhibit distinct cardiac electrophysiological responses to bepridil compared to dogs, potentially serving as a useful model for remodeled human hearts.
Species differences in bepridil sensitivity warrant model-specific interpretation; leaves open microminipig utility for cardiac electrophysiology research.
Since microminipig is becoming attractive model for various cardiac electropharmacological applications, which may meet consideration of 3Rs. We characterized microminipigs by analyzing how multi-ionic channel inhibitor bepridil may affect their in situ hearts in comparison with dogs. Bepridil in doses of 0.3 and 3.0 mg/kg were intravenously administered over 10 min under halothane anesthesia (n = 4). Microminipigs may be less sensitive for ICaT inhibition of bepridil, whereas they are more responsive to INa, IKr and IKs suppression than dogs. This information would help predict cardiovascular effects of a drug in patients with the remodeled hearts having similar electrophysiological profile to microminipigs.
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Nunoi et al. (2020) studied this question.
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