Why the study?
Does platelet-activating factor alter the expression of MMP-1 and TIMP-1 in human uterine cervical fibroblasts?
Population
Human uterine cervical fibroblasts obtained from patients who underwent cesarean section at term
Comparison
Platelet-activating factor (PAF) vs Control cultures
Design
Preclinical
Authors
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May implicate PAF in cervical ripening; hypothesis-generating for human parturition and requires validation.
Does platelet-activating factor alter the expression of MMP-1 and TIMP-1 in human uterine cervical fibroblasts?
PAF induces an imbalance between MMP-1 and TIMP-1 expression in human uterine cervical fibroblasts, which may contribute to cervical ripening during parturition.
Sugano et al. (2000) studied this question.
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