Why the study?
Do centrally acting drugs (metamphetamine vs pentobarbitone) modify catecholamine excretion during mental work?
Population
Subjects undergoing mild stress induced by performing psychological tasks
Comparison
Metamphetamine (10 mg) vs Pentobarbitone (200 mg) and inactivity
Design
Other
Authors
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Adrenaline excretion may mark central drug effects on mental stress; leaves open its value as a clinical biomarker.
Do centrally acting drugs (metamphetamine vs pentobarbitone) modify catecholamine excretion during mental work?
Metamphetamine increases adrenaline excretion during mental work compared to pentobarbitone, indicating that adrenaline excretion is a sensitive indicator of drug-modified stress states.
Frankenhaeuser et al. (1962) studied this question.
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