Electrospun PGS:PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy
Population
Primary human valvular interstitial cells (VICs)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
PGS:PCL scaffolds support VIC alignment and matrix production; leaves open in vivo durability and clinical translation.
Structured PICO
P
Population
Primary human valvular interstitial cells (VICs)
I
Intervention
Fibrous poly(glycerol sebacate):poly(caprolactone) (PGS:PCL) scaffolds containing aligned fibers fabricated via directional electrospinning
O
Outcome
Cell attachment, alignment, and biochemical activity (gene expression of collagen, vimentin, and smooth muscle actin)surrogate
Fibrous PGS:PCL scaffolds seeded with human VICs mimic the structure and mechanical properties of native valve leaflet tissues, demonstrating potential for heart valve tissue engineering.
Cite This Study
Masoumi et al. (2014) studied this question.