The purification of eleven neurotoxins from the venom of three scorpions (Androctonus australis Hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus) has been performed by Sephadex G‐50 filtration (with and without recycling) and equilibrium chromatography on Amberlite CG‐50, CM‐Sephadex C‐50 and DEAE‐Sephadex A‐50. All the chromatographic steps were carried out in ammonium acetate buffers. Purity of the neurotoxins was assessed by amino acid analysis and zone electrophoresis. All have a molecular weight of about 7000 daltons and do not contain methionine. As shown by amino acid composition and chain length scorpion neurotoxins show a high degree of homology.
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Miranda et al. (1970) studied this question.
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