What does this research mean for the field?

Left bundle branch area pacing maintains stable electrophysiological parameters, significantly improves ejection fraction in patients with baseline left ventricular dysfunction, and carries minimal complications through 12 months of follow-up. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the electrophysiological, echocardiographic, and clinical outcomes of left bundle branch area pacing over a 12-month follow-up period.

July 1, 2026International Journal of Applied and Basic Medical Research

Assessment of Clinical Outcomes and Electrophysiological Parameters of Left Bundle Branch Area Pacing: A Single-center Prospective Study with 12-month Follow-up

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Why the study?

Comprehensive assessment of left bundle branch pacing outcomes across various indications and over extended follow-up periods is limited.

Does left bundle branch area pacing (LBBAP) improve electrophysiological parameters and cardiac function in patients with symptomatic bradyarrhythmia and left ventricular dysfunction?

Population

63 patients aged 18–80 with symptomatic bradyarrhythmia and left ventricular dysfunction

Comparison

Pre- vs post-implantation assessments at 3, 6, and 12 months

Design

Single-center prospective cohort study

Follow-up

12 months

Authors

NANaved AslamPublic Works Department Buildings and Roads AGAnshuman GuptaDayanand Medical College & Hospital BJBhavuk JaiswalFortis Escorts Heart Institute

Discussion

Member takes

Implication

May support LBBAP in bradyarrhythmia with LV dysfunction; leaves open need for RCTs to confirm benefits versus standard pacing.

Key Points

To evaluate the electrophysiological, echocardiographic, and clinical outcomes of left bundle branch area pacing over a 12-month follow-up period.
Single-center prospective cohort study enrolling 63 patients aged 18–80 with symptomatic bradyarrhythmia and left ventricular dysfunction.
Patients underwent left bundle branch area pacing using Select Secure pacing leads, with repeated clinical assessments conducted at 3, 6, and 12 months post-implantation.
Successful implantation was achieved in 100% of patients, with selective left bundle branch capture confirmed in 78.9%.
Pacing lead parameters, including capture threshold, paced QRS duration, pacing impedance, and R-wave amplitude, remained stable from baseline through 3, 6, and 12 months.
Patients with reduced baseline ejection fraction demonstrated significant improvements across all follow-up intervals (3 to 6, 6 to 12, and 3 to 12 months), with minimal procedural and late complications.

Structured PICO

Does left bundle branch area pacing (LBBAP) improve electrophysiological parameters and cardiac function in patients with symptomatic bradyarrhythmia and left ventricular dysfunction?

Population

63 patients aged 18–80 with symptomatic bradyarrhythmia and left ventricular dysfunction

Intervention

Left bundle branch area pacing (LBBAP) using Select Secure pacing leads

Outcome

Electrophysiological parameters, cardiac function, and adverse events at 3, 6, and 12 monthssurrogate

Left bundle branch area pacing is a safe and effective strategy that maintains stable electrophysiological parameters and improves cardiac function in patients with bradyarrhythmia and LV dysfunction over 12 months.

Cite This Study

Aslam et al. (2026) studied this question.

synapsesocial.com/papers/6a8a645caf6b08ee8d72327f https://doi.org/10.4103/ijabmr.ijabmr_94_26

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