INTERFERON is a term used by Isaacs and Lindenmann1 to designate a soluble factor produced by the interaction of inactivated influenza virus with chick chorioallantoic tissue. Chick chorioallantoic tissue, after being incubated with this factor, does not support the multiplication of influenza and other myxoviruses as well as untreated controls. Its discovery introduced important new considerations in the understanding and evaluation of viral interference. Up till then, the interference of one virus with another, although poorly understood as far as its mechanism was concerned, was assumed to be the direct effect of the interfering virus or component of virus.2 Interferon . . .
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Monto Ho (1962) studied this question.
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