Why the study?
Does isradipine attenuate endothelin-induced regional vasoconstriction in anesthetized rabbits?
Population
20 anesthetized rabbits
Comparison
Isradipine 10 micrograms/kg infusion vs Vehicle infusion
Design
Preclinical
Authors
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Isradipine partially blunts endothelin effects in rabbits; leaves open whether L-type calcium blockade translates to human vasoconstriction.
Does isradipine attenuate endothelin-induced regional vasoconstriction in anesthetized rabbits?
Isradipine blunts many endothelin-induced hemodynamic effects in rabbits, suggesting endothelin-mediated vasoconstriction partially involves L-type calcium channel activation.
Hof et al. (1990) studied this question.
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