Why the study?
Does isradipine alter peripheral hemodynamic reflex responses in patients with mild-to-moderate essential hypertension?
Population
n=9 patients with mild-to-moderate essential hypertension, mean age 48 years
Comparison
Isradipine 5 mg twice daily for six weeks vs Placebo (crossover design)
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
six weeks
Authors
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Supports isradipine for mild-to-moderate hypertension via favorable reflex profile; extends RCT evidence on dihydropyridine hemodynamic effects.
Does isradipine alter peripheral hemodynamic reflex responses in patients with mild-to-moderate essential hypertension?
Isradipine lowers blood pressure in mild-to-moderate essential hypertension partially through peripheral vasodilatation and attenuation of hemodynamic reflex responses.
Duprez et al. (1991) studied this question.
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