What question did this study set out to answer?

To synthesize a simple, dual pH- and temperature-responsive nanogel adhesive capable of stable hydrogel interfacial bonding without requiring secondary curing steps.

December 16, 2025Macromolecular Rapid Communications

pH‐ and Temperature‐Responsive Nanogel Adhesive for Tunable Interfacial Bonding of Hydrogel Materials

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Authors

CLChunhui Li HYHuan Yu QYQing Yang

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Overview

In vitro study demonstrates tunable hydrogel bonding via dual-responsive nanogel adhesives, highlighting simple and biocompatible material design.

Key Points

To synthesize a simple, dual pH- and temperature-responsive nanogel adhesive capable of stable hydrogel interfacial bonding without requiring secondary curing steps.
Synthesized the nanogel adhesive using a one-step precipitation polymerization of N-isopropylacrylamide (NIPAM) and 3-acrylamidophenylboronic acid (AAPBA).
Measured interfacial shear and tensile bonding strengths using 15 µL of adhesive dispersion on hydroxyl-rich hydrogel substrates across varying pH levels, particle sizes, and concentrations.
Evaluated biological safety through in vitro hemocompatibility assays and cell viability testing.
Application of 15 µL nanogel dispersion achieved an interfacial shear strength of 7.0 ± 1.4 kPa and a tensile strength of 15.7 ± 4.2 kPa.
Adhesion strength demonstrated reversible responsiveness and tunability governed by dispersion pH, nanogel particle size, and concentration.
In vitro biological evaluations confirmed favorable hemocompatibility and high cell viability.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a8a73f05c716ca1a5d471be https://doi.org/10.1002/marc.202500861

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December 16, 2025Macromolecular Rapid Communications

pH‐ and Temperature‐Responsive Nanogel Adhesive for Tunable Interfacial Bonding of Hydrogel Materials

View Full Paper

Ask AI

Bookmark

Authors

CLChunhui Li HYHuan Yu QYQing Yang

Discussion

Member takes

Overview

In vitro study demonstrates tunable hydrogel bonding via dual-responsive nanogel adhesives, highlighting simple and biocompatible material design.

Key Points

To synthesize a simple, dual pH- and temperature-responsive nanogel adhesive capable of stable hydrogel interfacial bonding without requiring secondary curing steps.
Synthesized the nanogel adhesive using a one-step precipitation polymerization of N-isopropylacrylamide (NIPAM) and 3-acrylamidophenylboronic acid (AAPBA).
Measured interfacial shear and tensile bonding strengths using 15 µL of adhesive dispersion on hydroxyl-rich hydrogel substrates across varying pH levels, particle sizes, and concentrations.
Evaluated biological safety through in vitro hemocompatibility assays and cell viability testing.
Application of 15 µL nanogel dispersion achieved an interfacial shear strength of 7.0 ± 1.4 kPa and a tensile strength of 15.7 ± 4.2 kPa.
Adhesion strength demonstrated reversible responsiveness and tunability governed by dispersion pH, nanogel particle size, and concentration.
In vitro biological evaluations confirmed favorable hemocompatibility and high cell viability.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a8a73f05c716ca1a5d471be https://doi.org/10.1002/marc.202500861

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