Why the study?
Are mitochondrial respiration and microRNA expression altered in the atrial tissue of patients with atrial fibrillation compared to sinus rhythm?
Are mitochondrial respiration and microRNA expression altered in the atrial tissue of patients with atrial fibrillation compared to sinus rhythm?
Mitochondrial respiration is increased and specific microRNAs are differentially expressed in the atria of patients with atrial fibrillation, suggesting their involvement in AF pathophysiology.
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These atrial changes are hypothesis-generating; leaves open causal roles of mitochondrial respiration and miRNAs in AF and need for prospective validation.
Slagsvold et al. (2014) studied this question.
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