Synthetic Studies toward Potent Cytotoxic Agent Amphidinolide B: Synthesis of the Entire Cl-C13 Moiety of the Bottom Half

Sharpless asymmetric dihydroxylation and Nozaki-Hiyama-Kishi’s Cr(II)-mediated coupling between an α-alkoxyaldehyde and a vinyl iodide are the key steps in the stereoselective synthesis of the entire C1-C13 segment of the bottom-half of amphidinolide B.