October 1, 1999Clinical CardiologyOpen Access

Prolongation of the QT interval in children with liver failure

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Why the study?

Does liver transplantation reverse QT prolongation in children with hepatic failure?

Population

38 pediatric patients undergoing evaluation for liver transplantation, with normal serum electrolytes…

Comparison

Liver transplantation vs Patients with a normal QT interval

Design

Cohort

Authors

SFSteven B. FishbergerPediatric / Congenital Cardiology ARAnthony F. RossiMiami Children's Hospital NPNanci PittmanIcahn School of Medicine at Mount Sinai

Discussion

Member takes

Implication

May support QTc monitoring in pediatric liver failure; leaves open causality and generalizability pending larger prospective studies.

Structured PICO

Does liver transplantation reverse QT prolongation in children with hepatic failure?

Population

38 pediatric patients (mean age 6.5 +/- 7.2 years) undergoing evaluation for liver transplantation, with normal serum electrolytes, calcium, and magnesium, and not on medications known to prolong repolarization.

Intervention

Liver transplantation (for survivors with prolonged QT)

Comparator

Patients with a normal QT interval (for baseline comparisons)

Outcome

Prevalence of prolonged QTc (> 450 ms) and its reversibility following liver transplantationsurrogate

QTc prolongation occurs in a significant proportion of children with liver failure and appears to be reversible following liver transplantation.

Cite This Study

Fishberger et al. (1999) studied this question.

synapsesocial.com/papers/6a8a7614755d28965dfd6af6 https://doi.org/10.1002/clc.4960221013

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Prolongation of the QT interval in children with liver failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prolongation of the QT interval in children with liver failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider