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September 1, 1965Circulation ResearchOpen Access

Durations of Transmembrane Action Potentials and Functional Refractory Periods of Canine False Tendon and Ventricular Myocardium:

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Population

Canine false tendon and ventricular myocardium in vitro preparations

Comparison

Alterations in ionic composition, perfusion… vs Different cell types and baseline conditions

Design

Preclinical

Authors

JPJames B. PrestonUnited States Department of Veterans AffairsGMGordon K. MoeUtica College

Discussion

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Overview

No immediate clinical implications; leaves open differential refractoriness in human ventricular tissue.

Structured PICO

P
Population
Canine false tendon and ventricular myocardium (papillary muscle, epicardial, and endocardial cells) in vitro preparations
I
Intervention
Alterations in ionic composition, perfusion fluid (blood/plasma vs Tyrode's), time lapse, acetylcholine/epinephrine addition, and varying cycle lengths
C
Comparator
Different cell types (false tendon vs papillary muscle, epicardial vs endocardial) and baseline conditions
O
Outcome
Durations of transmembrane action potentials and functional refractory periodssurrogate

This preclinical study demonstrates that cycle length is the primary determinant of differential functional refractory periods and action potential durations between canine false tendon and papillary muscle cells.

Cite This Study

Preston et al. (1965) studied this question.

synapsesocial.com/papers/6a8a76f9b4e829b19bd484bfhttps://doi.org/10.1161/01.res.17.3.259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Cycle Length Upon Refractory Period of Auricles, Ventricles, and A-V Node in the Dog1956 · 160 citations
  2. 2Atrioventricular transmission in young mammals1959 · 71 citations
  3. 3Prevention of Ventricular Tachycardia and Fibrillation by Intravenous Isoproterenol and Epinephrine1963 · 84 citations
  4. 4Transmyocardial Temperature Gradient in Dog and Man: Relation to the Polarity of the T wave of the Electrocardiogram1964 · 81 citations
  5. 5Electrophysiology of the Heart.1960 · 1,317 citations