Population
Autopsy brain tissue samples from six HCV-infected patients
Design
Case_series
Authors
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Hypothesis-generating for CNS HCV involvement; does not yet alter clinical management and needs prospective validation.
The detection of HCV negative-strand RNA in brain tissue suggests that HCV can replicate in the central nervous system, potentially explaining the physical and mental well-being changes in chronic hepatitis C patients.
Radkowski et al. (2002) studied this question.
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