What question did this study set out to answer?

To evaluate the feasibility and functional outcome of using a peripheral nerve allograft with temporary immunosuppression to repair an extensive peripheral nerve defect.

October 1, 1992Plastic & Reconstructive Surgery

Clinical Application of Peripheral Nerve Transplantation

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Authors

SMSusan E. MackinnonWashington University in St. Louis AHAlan HudsonUniversity of Oxford

Discussion

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Implication

Case report demonstrates nerve regeneration and sensory recovery following sciatic nerve allograft in a pediatric patient, suggesting allografts are viable for extensive injuries.

Key Points

To evaluate the feasibility and functional outcome of using a peripheral nerve allograft with temporary immunosuppression to repair an extensive peripheral nerve defect.
A 23-cm, 10-cable sciatic nerve allograft reconstruction was performed in an 8-year-old male patient (N=1) in September 1988.
Immunosuppressive therapy with Cyclosporin A was administered postoperatively for 2 years.
Clinical follow-up was evaluated 44 months after transplantation, corresponding to 19 months after the discontinuation of Cyclosporin A.
Nerve regeneration was observed across the entire 23-cm allograft construct.
The patient achieved functional sensory recovery in the foot at 44 months post-surgery and 19 months following Cyclosporin A cessation.

Cite This Study

Mackinnon et al. (1992) studied this question.

synapsesocial.com/papers/6a8a7b305246293882fd907b https://doi.org/10.1097/00006534-199210000-00024

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Implication

Case report demonstrates nerve regeneration and sensory recovery following sciatic nerve allograft in a pediatric patient, suggesting allografts are viable for extensive injuries.

Clinical Application of Peripheral Nerve Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Application of Peripheral Nerve Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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