Population
Isolated preparations of atrial specialized conduction fibers and ventricular Purkinje fibers from dogs
Design
Preclinical
Authors
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These canine fiber mechanisms suggest digitalis arrhythmogenesis pathways; leaves open clinical relevance pending human validation.
Acetylstrophanthidin induces transient depolarizations in both atrial and ventricular specialized conduction fibers of dogs, with differential responses to acetylcholine.
Hashimoto et al. (1973) studied this question.
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