Why the study?
African swine fever has reached panzootic dimensions without available commercial vaccines, and the safety of the live attenuated vaccine candidate ASFV-G-∆MGF required assessment.
Population
Animals in an in vivo model
Comparison
Live attenuated vaccine candidate ASFV-G-∆MGF undergoing forced animal passaging
Design
In vivo reversion to virulence study
Authors
Loading...
Indicates genetic instability risk for ASFV-G-∆MGF; leaves open need for further attenuation and stability testing.
The ASFV-G-∆MGF live attenuated vaccine candidate did not show significant reversion to virulence upon forced animal passaging, though a variant with increased replication emerged, highlighting the need for further safety characterization.
Deutschmann et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: