Why the study?
Does thyroidectomy impair ventricular relaxation and SR calcium uptake activity in spontaneously hypertensive rats and Wistar-Kyoto controls?
Population
Spontaneously hypertensive rats (SHR) and nonhypertrophic Wistar-Kyoto rat (WKY) controls
Comparison
Thyroidectomy of 8 weeks duration vs Euthyroid SHR and WKY controls
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothyroidism may worsen diastolic impairment in hypertension models; hypothesis-generating for thyroid-SR calcium interactions, needs translational studies before clinical relevance.
Does thyroidectomy impair ventricular relaxation and SR calcium uptake activity in spontaneously hypertensive rats and Wistar-Kyoto controls?
Hypothyroidism induced by thyroidectomy further impairs ventricular relaxation and SR calcium uptake in spontaneously hypertensive rats.
Rodgers et al. (1986) studied this question.
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