Why the study?
Do L-arginine analogues reduce aldosterone secretion in rats?
Population
Anesthetized rats (intact and anephric)
Comparison
L-arginine analogues vs Control animals
Design
Preclinical
Authors
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Hypothesis-generating in rats for NO-mediated aldosterone control; leaves open human relevance and precludes clinical use.
Do L-arginine analogues reduce aldosterone secretion in rats?
L-arginine analogues attenuate aldosterone secretion in rats by inhibiting the adrenal steroidogenic effects of angiotensin II and/or reducing plasma renin/angiotensin levels.
Simmons et al. (1995) studied this question.
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