What question did this study set out to answer?

To extract, structurally characterize, and evaluate the antimicrobial and wound-healing properties of an exopolysaccharide derived from the yeast Papiliotrema terrestris PT22AV.

June 25, 2022Journal of Advanced ResearchOpen Access

Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing

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To extract, structurally characterize, and evaluate the antimicrobial and wound-healing properties of an exopolysaccharide derived from the yeast Papiliotrema terrestris PT22AV.
Characterized the molecular weight, morphology, and monosaccharide composition of exopolysaccharides (EPS) isolated from molecularly identified P. terrestris PT22AV.
Assessed in vitro antibacterial activity against E. coli, S. aureus, and S. epidermidis, along with cytocompatibility in human fibroblast and macrophage cell lines.
Conducted in vivo animal evaluations to measure dose-dependent wound closure over 14 days relative to positive and negative controls.
The extracted EPS had a molecular weight of 202 kDa and consisted of 97% mannose and 3% glucose.
EPS at 2 mg/mL exhibited >80% antibacterial activity against E. coli, S. aureus, and S. epidermidis while maintaining cytocompatibility with human fibroblasts and macrophages.
Animal models displayed dose-dependent healing, with the 10 mg/mL concentration achieving greater wound closure after 14 days compared to both negative and positive controls.

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Implication

Preclinical study demonstrates accelerated skin wound closure in animal models, suggesting potential as a biocompatible dressing for wound healing.

Cite This Study

Hamidi et al. (2022) studied this question.

synapsesocial.com/papers/6a8a86d3ea82e62cf6fd6257 https://doi.org/10.1016/j.jare.2022.06.012

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Implication

Preclinical study demonstrates accelerated skin wound closure in animal models, suggesting potential as a biocompatible dressing for wound healing.

Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing

Key Points

Discussion

Implication

Cite This Study

Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing

Key Points

Discussion

Implication

Cite This Study

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